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Hormones, HRT, and Skin Aging: A Dermatologist’s Guide to Anti-Aging in San Francisco

hormone replacement for anti-aging with estrogen

Aging is inevitable—but how our skin shows its years can be influenced. Recent studies about estrogen, skin aging, and hormone replacement therapy (HRT) have reignited interest in how hormonal changes (especially during perimenopause and menopause) contribute to thinning skin, loss of elasticity, dryness, and wrinkles.

At our San Francisco dermatology practice, Dr. Caren Campbell takes a holistic, evidence-based approach to skin health. While we do not prescribe HRT, we stay up to date on the research so we can guide patients in making informed decisions. For women considering HRT, we encourage discussions with their gynecologist—who is specially trained in this area—while we focus on skin-directed therapies that prevent and reverse signs of aging.


The Role of Estrogen in Skin Aging

  • Estrogen receptors are present in skin cells, and estrogen supports collagen, elasticity, and hydration.

  • During menopause, declining estrogen levels accelerate skin thinning, loss of firmness, and fine lines.

  • Some studies show HRT may improve skin thickness and hydration, though results vary depending on hormone type, delivery method, and patient age.

This is why it’s so important to take a collaborative approach: your dermatologist for skin, your gynecologist for hormone health, and an overall plan tailored to you.


Practicing Within Scope: Skin Expertise + Trusted Resources

As a board-certified dermatologist in San Francisco, Dr. Caren Campbell is committed to practicing within the scope of her training. That means:

  • We do not prescribe HRT. Instead, we guide you on questions to ask your gynecologist, who can address whether hormone therapy is appropriate for you.

  • We focus on dermatologic anti-aging treatments in San Francisco that directly target wrinkles, sun damage, and volume loss.

  • We provide evidence-based guidance by pointing patients toward trusted resources created by physicians who are experts in perimenopause and menopause—helping you cut through the crowded, often non-expert space online.

Some of Dr. Campbell’s vetted recommendations include:

  • 🎧 Ovaryactive Podcast, hosted by physician experts in perimenopause and menopause.

  • 📖 The Menopause Manifesto by Dr. Jen Gunter, a gynecologist specializing in women’s health.

These resources help patients gain clarity from true experts, while Dr. Campbell addresses every aspect of skin health and aging in San Francisco.


Anti-Aging Treatments at Our San Francisco Dermatology Practice

  • Topical treatments: Prescription tretinoin, daily broad-spectrum sunscreen, and antioxidants like vitamin C and niacinamide.

  • Botox in San Francisco: Prevents deep wrinkles caused by repetitive muscle movement, helping patients maintain smooth, youthful skin.

  • Dermal fillers San Francisco: Restore youthful volume lost with age, weight changes, or breastfeeding, especially in the cheeks, under-eyes, and around the mouth.

  • Laser skin treatments in San Francisco: Target pigmentation, broken blood vessels, fine lines, and stimulate collagen renewal for healthier, firmer skin.


A Holistic Anti-Aging Plan

  • Daily regimen: Gentle cleanser, antioxidant serum, sunscreen, prescription retinoid at night.

  • In-office treatments: Botox every 3–4 months, fillers for volume restoration, and periodic laser or light treatments for sun damage and texture.

  • Lifestyle: Sleep, hydration, balanced nutrition, and no smoking.

  • Collaborative care: For patients considering HRT, Dr. Campbell offers dermatologic guidance while recommending discussions with your gynecologist.


Why Choose Dr. Caren Campbell, San Francisco Dermatologist

Skin aging is complex. Hormones matter, but so do sun exposure, genetics, and daily habits. At our San Francisco dermatology clinic, Dr. Caren Campbell helps you navigate all aspects of skin aging—combining advanced dermatology treatments like Botox, fillers, and lasers with medical-grade skincare tailored to your needs.

We stay informed about systemic therapies like HRT, but practice within the scope of dermatology, collaborating with gynecologists and recommending trusted resources where appropriate.

The result: a holistic, personalized plan designed to protect, restore, and rejuvenate your skin at every stage of life—right here in San Francisco.

References 

Viscomi B, Muniz M, Sattler S. Managing Menopausal Skin Changes: A Narrative Review of Skin Quality Changes, Their Aesthetic Impact, and the Actual Role of Hormone Replacement Therapy in Improvement. J Cosmet Dermatol. 2025 Sep;24 Suppl 4(Suppl 4):e70393. 
Zouboulis CC, Blume-Peytavi U, Kosmadaki M, et al. Skin, Hair and Beyond: The Impact of Menopause. Climacteric. 2022;25(5):434-442. 
Reus TL, Brohem CA, Schuck DC, Lorencini M. Revisiting the Effects of Menopause on the Skin: Functional Changes, Clinical Studies, in Vitro Models and Therapeutic Alternatives. Mech Ageing Dev. 2020;185:111193. 
Calleja-Agius J, Brincat M. The Effect of Menopause on the Skin and Other Connective Tissues. Gynecol Endocrinol. 2012;28(4):273-7. 
Raine-Fenning NJ, Brincat MP, Muscat-Baron Y. Skin Aging and Menopause: Implications for Treatment. Am J Clin Dermatol. 2003;4(6):371-8. 
Yang JL, Hodara E, Sriprasert I, Shoupe D, Stanczyk FZ. Estrogen Deficiency in the Menopause and the Role of Hormone Therapy: Integrating the Findings of Basic Science Research With Clinical Trials. Menopause. 2024;31(10):926-939. 
Hall G, Phillips TJ. Estrogen and Skin: The Effects of Estrogen, Menopause, and Hormone Replacement Therapy on the Skin. J Am Acad Dermatol. 2005;53(4):555-68. 
Calleja-Agius J, Brincat M, Borg M. Skin Connective Tissue and Ageing. Best Pract Res Clin Obstet Gynaecol. 2013;27(5):727-40.
Windhager S, Mitteroecker P, Rupić I, et al. Facial Aging Trajectories: A Common Shape Pattern in Male and Female Faces Is Disrupted After Menopause. Am J Phys Anthropol. 2019;169(4):678-688. 
Levin YS. Cosmetic Dermatology in Menopause. Menopause. 2022;29(3):344-350. 
Wilkinson HN, Hardman MJ. A Role for Estrogen in Skin Ageing and Dermal Biomechanics. Mech Ageing Dev. 2021;197:111513. 
Wilkinson HN, Hardman MJ. The Role of Estrogen in Cutaneous Ageing and Repair. Maturitas. 2017;103:60-64.